With ‘Trojan Horse’ Approach, Enzyme Able to Cross into Brains of Mouse Models of Sanfilippo A in Study

A new treatment approach effectively carried the enzyme defective in Sanfilippo type A syndrome into the brains of mice in a disease model, researchers report, suggesting the strategy used may be of future importance to patients. The study, “Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan…

Fusion Protein Effectively Reaches Brains of Mice with Sanfilippo Syndrome, Study Shows

Treating Sanfilippo syndrome type A (SSA) may be possible with a fusion protein that effectively reaches the brain, according to lab research with mice. The study, “Reduction in Brain Heparan Sulfate with Systemic Administration of an IgG Trojan Horse-Sulfamindase Fusion Protein in the Mucopolysaccharidosis Type IIIA Mouse,” appeared…