Posts by: Ashraf Malhas, PhD

News

Among all four subtypes of Sanfilippo syndrome (also called mucopolysaccharidosis type III, or MPS III), Sanfilippo type B is the most frequent subtype among the Taiwanese population, according to ... Read more

August 7, 2018August 7, 2018

Early Diagnosis Vital for Counseling At-risk Sanfilippo Type B Families, Study Shows

News

Long-term clinical course examination is important for diagnosing Sanfilippo syndrome type B, because early and accurate diagnosis can provide important information for family planning by those at risk of ... Read more

August 2, 2018August 2, 2018

Study Outlines Methods to Reduce Risks Linked to Anesthesia for Sanfilippo Patients

News

Sanfilippo syndrome patients are typically considered at high risk when undergoing anesthesia because of the possibility of airway obstruction, but the use of two specific anesthetics, along with adequate ... Read more

July 12, 2018July 12, 2018

Rare Klüver-Bucy Syndrome Associated with Sanfilippo Type C in Case Report

News

A recent case report identified two siblings with Sanfilippo syndrome type C (MPSIIIC) who were also diagnosed with Klüver-Bucy syndrome, indicating a previously unknown association between the rare neurological ... Read more

July 5, 2018July 5, 2018

Sanfilippo Type IIIA Linked to High Levels of Creatinine Kinase Enzyme in Rare Case Study

News

A rare and unexpected case of Sanfilippo type IIIA was reported in a 13-month-old child following the observance of high levels of the enzyme creatinine kinase in the child’s ... Read more

June 28, 2018June 28, 2018

Molecule Called Trehalose Lowered Inflammation and Preserved Vision in Sanfilippo Mouse Model, Study Reports

News

Treating a mouse model of Sanfilippo with a small molecule, called trehalose, may be a viable therapeutic approach for people with this syndrome, researchers suggest. Their study, “Trehalose reduces ... Read more

June 21, 2018June 21, 2018

MRI Analysis Identifies Jaw Bone Defects Specific to MPS Types, Including Sanfilippo

News

A retrospective analysis on magnetic resonance images from patients with mucopolysaccharidoses (MPS), including Sanfilippo syndrome, revealed jaw bone defects specific to certain disease subtypes. Researchers also found that some ... Read more

June 12, 2018June 12, 2018

With ‘Trojan Horse’ Approach, Enzyme Able to Cross into Brains of Mouse Models of Sanfilippo A in Study

News

A new treatment approach effectively carried the enzyme defective in Sanfilippo type A syndrome into the brains of mice in a disease model, researchers report, suggesting the strategy used ... Read more

June 7, 2018June 7, 2018

Test for Sanfilippo Syndrome Type A Shows Promise for Screening Newborns

News

A new test that uses dried blood spots has been developed for diagnosing Sanfilippo syndrome type A. This test would prove especially useful for disease screening in newborns, according to a study. ... Read more

May 31, 2018May 31, 2018

Levels of Specific Sugar May Be Potential Diagnostic Tool for Sanfilippo Syndrome, Other MPS Types

News

Using a specific technique to measure the levels of a sugar called glycosaminoglycan in blood and urine can identify all types of mucopolysaccharidosis (MPS) — including Sanfilippo syndrome — ... Read more