Author Archives: Marta Figueiredo PhD

Sanfilippo Type A Causes Toxic Buildup of Several Molecules in Various Brain Regions, Mouse Study Shows

Sanfilippo syndrome type A leads to toxic accumulation of several molecules in nerve cell axons — the structures responsible for conducting messages — of different brain regions, which correlates with disease progression, according to a mouse study. Researchers believe this toxic accumulation is likely to impair nerve cell communication and…

Pentosan Polysulfate Shows Promise in Mouse Study of Sanfilippo Type A

Subcutaneous pentosan polysulfate (PPS) treatment reduces overall inflammation and brain degeneration, improving hyperactivity/anxiety and learning behavior in Sanfillipo syndrome type A, according to a mouse study. The study, “Pentosan Polysulfate Treatment of Mucopolysaccharidosis Type IIIA Mice,” was published in the Journal of Inherited Metabolic Disease.