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Hearing Loss Common in Young Patients with Different Types of MPS Disorders, Study Says

Mild to moderate hearing loss is common among children and young adults with different mucopolysaccharidosis (MPS) diseases, including Sanfilippo syndrome, a small study reports. The study, “Audiometric evaluation in individuals with muco-polysaccharidosis,” appeared in the journal Clinics. MPS disorders are identified by deficiencies in lysosomal enzymes involved…

Heparan Sulfate Buildup Not Directly Linked to MPSIIIA Symptom Onset, Mouse Study Shows

Heparan sulfate accumulation is not a good indicator of Sanfilippo syndrome type A symptom onset, a new mouse model of the disease suggests. This finding, reported in the study, “A novel conditional Sgsh knockout mouse model recapitulates phenotypic and neuropathic deficits of Sanfilippo syndrome,” reiterates other…